|
KMID : 0390220010120010054
|
|
Journal of Clinical Otolaryngology, Head and Neck Surgery
2001 Volume.12 No. 1 p.54 ~ p.60
|
|
|
Integrated process of Eosinophils, Fibronectin and Cytokines in the Growth of Nasal Polyp
|
|
이봉희/Bong Hee Lee
표경보/이환호/안경모/이영수/이한국/이강대/Kyung Bo Pye/Hwan Ho Lee/Kyoung Mo Ahn/Young Soo Lee/Han Kook Lee/Kang Dae Lee
|
|
|
Abstract
|
|
|
Background and objectives: Nasal polyp is a common chronic disease of the nasal or paranasal mucosa, with histologically chatacterized by eosinophil infiltration and edema formation. This study was performed to investigate an integrated
process
of eosinophils, fibronectin, and cytokines(IL-5, TGFβ1) in the pathogenesis and growth of nasal polyp.
Materials and Methods: Nasal polyps samples were taken from 71 patients during endoscopic nasal surgery. Sampled nasal polyps were differentiated by size, extent of rhinosinusitis, morphologic characteristics, infiltration cell types and
fibronectin positivity. Cytokine protein content was measured by ELISA. Then correlation among these factors was analyzed.
Results: Nasal polyps showing edematous morphology, severe CT stage were significantly large in size. Significant correlation among edematous morphology and fibronectin expression, cytokin protein content were also recognized. Fibronectin
positivity was significantly higher in the eosinophil infiltration type.
Conclusion: These findings suggest that integrated process of eosinophil, fibronectin, and cytokine(IL-5, TGFβ1)may play a key role in edema formation, which contributes to the growth of nasal polyps.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|